KEA1-97

KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM) . KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1].

Product Specifications

CAS Number

[2138882-71-8]

Product Name Alternative

Desmethyldoxepin (hydrochloride),4-Nitrophenylphosphorylcholine; 4-Nitrophenylphosphorylcholine; O-(4-Nitrophenylphosphoryl)choline

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kea1-97.html

Concentration

10mM

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=NC(Cl)=NC(NC2=CC=C(C=C2)C3=CC=C(C=C3)F)=N1

Molecular Formula

C15H9Cl2FN4

Molecular Weight

335.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12 (10) :2522-2528.