Angoline
Product Specifications
UNSPSC Description
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
Target Antigen
Interleukin Related; STAT
Type
Natural Products
Related Pathways
Immunology/Inflammation;JAK/STAT Signaling;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/angoline.html
Purity
99.67
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC
Molecular Weight
379.41
References & Citations
[1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N7674/Angoline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N7674/Angoline-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
21080-31-9
Available Sizes
Curated Selection
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