Angoline

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

Product Specifications

CAS Number

[21080-31-9]

UNSPSC

12352005

Hazard Statement

H301, H335

Target

Interleukin Related; STAT

Type

Natural Products

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/angoline.html

Purity

99.67

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC

Molecular Formula

C22H21NO5

Molecular Weight

379.41

Precautions

H301, H335

References & Citations

[1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21 (8-9) :1088-91.