Angoline
Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].
Product Specifications
CAS Number
21080-31-9
UNSPSC
12352005
Hazard Statement
H301, H335
Target
Interleukin Related; STAT
Type
Natural Products
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/angoline.html
Purity
99.67
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
CN1C2=C3C(C=C4OCOC4=C3)=CC=C2C5=C(C(OC)=C(OC)C=C5)C1OC
Molecular Formula
C22H21NO5
Molecular Weight
379.41
Precautions
H301, H335
References & Citations
[1]Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21 (8-9) :1088-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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