QCA570

QCA570 is a PROTAC connected by ligands for Cereblon and BET, with an IC50 of 10 nM for BRD4 BD1 Protein.

Product Specifications

CAS Number

[2207569-08-0]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/QCA570.html

Purity

99.30

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

O=C(N(C1CCC(NC1=O)=O)C2)C3=C2C(C#CCCCN4N=CC(C#CC(S5)=C(CC6=CC=CC=C6)C(COC7)=C5N8C7=NN=C8C)=C4)=CC=C3

Molecular Formula

C39H33N7O4S

Molecular Weight

695.79

References & Citations

[1]Qin C, et al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61 (15) :6685-6704.