Exatecan-d5 (mesylate)

Exatecan-d5 (DX8951f-d5) mesylate is deuterium labeled Exatecan mesylate (HY-13631A) . Exatecan mesylate is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL) . Exatecan mesylate can be used in cancer research[1].

Product Specifications

CAS Number

[2819276-88-3]

Product Name Alternative

DX8951f-d5; Deuterated labeled Exatecan (mesylate)

UNSPSC

12352005

Hazard Statement

H300, H340, H360

Target

ADC Payload; Isotope-Labeled Compounds; Topoisomerase

Type

Isotope-Labeled Compounds

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.83

Solubility

DMSO : 11.11 mg/mL (ultrasonic) |H2O : 1mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=S(C)(O)=O.O=C1[C@](O)(C(C([2H])([2H])[2H])([2H])[2H])C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O

Molecular Formula

C25H21D5FN3O7S

Molecular Weight

536.58

Precautions

H300, H340, H360

References & Citations

[1]Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86 (8) :776-82.