BRL-50481
BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.
Product Specifications
CAS Number
433695-36-4
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BRL-50481.html
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)C)=O
Molecular Formula
C9H12N2O4S
Molecular Weight
244.27
Precautions
H315, H319, H320
References & Citations
[1]Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun;8 (6) :733-51.|[2]Smith SJ, et al. Discovery of BRL 50481 [3- (N, N-dimethylsulfonamido) -4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol. 2004 Dec;66 (6) :1679-89.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE7
Available Sizes
Frequently Asked Questions
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