BRL-50481

BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.

Product Specifications

CAS Number

[433695-36-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BRL-50481.html

Purity

99.81

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)C)=O

Molecular Formula

C9H12N2O4S

Molecular Weight

244.27

Precautions

H315, H319, H320

References & Citations

[1]Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurologicaland inflammatory disorders. Expert Opin Drug Discov. 2013 Jun;8 (6) :733-51.|[2]Smith SJ, et al. Discovery of BRL 50481 [3- (N, N-dimethylsulfonamido) -4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol. 2004 Dec;66 (6) :1679-89.