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Butabindide (oxalate)

Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation[1][2].

Product Specifications

CAS Number

185213-03-0

Product Name Alternative

UCL-1397 (oxalate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/butabindide-oxalate.html

Purity

98.98

Solubility

H2O : 39 mg/mL (ultrasonic; warming)

Smiles

O=C([C@H]1N(C([C@@H](N)CC)=O)C2=C(C=CC=C2)C1)NCCCC.O=C(O)C(O)=O

Molecular Formula

C19H27N3O6

Molecular Weight

393.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48 (23) :7333-42.|[2]Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380 (6573) :403-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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