YOK-2204
YOK-2204 is a ligand of p62-ZZ domain. YOK-2204 can activate p62-dependent selective macroautophagy. YOK-2204 can be used for AUTOTAC design[1].
Product Specifications
CAS Number
[2409959-99-3]
UNSPSC
12352005
Target
P62
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yok-2204.html
Purity
98.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H](CNC(C)C)COC1=CC(OCCC2=CC=CC=C2)=C(OCCC3=CC=CC=C3)C=C1
Molecular Formula
C28H35NO4
Molecular Weight
449.58
References & Citations
[1]Ji CH, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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