Pregnenolone
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Product Specifications
CAS Number
145-13-1
Product Name Alternative
3β-Hydroxy-5-pregnen-20-one
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Cannabinoid Receptor; Endogenous Metabolite; TRP Channel
Type
Natural Products
Related Pathways
Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Pregnenolone.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
C[C@@](C1=CC2)(CC[C@H](O)C1)[C@]3([H])[C@]2([H])[C@@](CC[C@@H]4C(C)=O)([H])[C@]4(C)CC3
Molecular Formula
C21H32O2
Molecular Weight
316.48
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
CB1; Human Endogenous Metabolite
Citation 01
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Grainyhead like protein 1 homolog (GRHL1) (NM_014552) Human Over-expression Lysate
![Thyroid Hormone Receptor alpha (THRA) Mouse Monoclonal Antibody [Clone ID: OTI5E12]](https://cdn.genprice.uk/products/937/68dd18b9061270361e907cbf/imageurl/cf805258.webp)
Thyroid Hormone Receptor alpha (THRA) Mouse Monoclonal Antibody [Clone ID: OTI5E12]
![Calreticulin Recombinant Rabbit Monoclonal Antibody [SU37-03]](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea81867/imageurl/et1608-60.webp)