TCS-OX2-29

TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2].

Product Specifications

CAS Number

[372523-75-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Orexin Receptor (OX Receptor)

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/TCS-OX2-29.html

Purity

99.55

Solubility

DMSO : 25 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic)

Smiles

CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O

Molecular Formula

C23H31N3O3

Molecular Weight

397.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13 (24) :4497-9.|[2]R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171 (2) : 351-363.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

OX2 Receptor

Available Sizes

Curated Selection

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