Anti-SOX-10 Antibody

Mouse Monoclonal Antibody specific to SOX-10

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-SOX-10 Mouse Monoclonal Antibody

Gene Name

SOX10

NCBI Gene ID

UniProt

P56693

Cellular Locus

Cytoplasm, Nucleus, Mitochondrion outer membrane, Peripheral membrane protein, Cytoplasmic side

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human SOX-10.

Target Antigen

Transcription factor SOX-10

Target

SOX-10

Clonality

Monoclonal

Isotype

IgG2b

Type

Antibody

Applications

IHC

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Tris

Function

Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {UniProtKB:O55170, UniProtKB:Q04888, PubMed:21965087}.

Additionnal Information

<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

Human SOX-10. Reactivity with other species has not been investigated.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

Buffer pH

pH 7.3-7.7

Target Background

SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurobromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg- Shah and Waardenburg-Hirschsprung disease.