Glycycoumarin
Glycycoumarin is a potent antispasmodic agent. Glycycoumarin is a major bioactive coumarin of licorice and exhibits antispasmodic activity. Glycycoumarin also has hepatoprotective effect. Glycycoumarin can be used for the research of abdominal pain and liver diseases[1][2].
Product Specifications
CAS Number
94805-82-0
UNSPSC
12352005
Target
AMPK; Keap1-Nrf2
Type
Natural Products
Related Pathways
Epigenetics; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/glycycoumarin.html
Purity
99.98
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C(O)C=C2O)=CC3=C(OC)C(C/C=C(C)\C)=C(O)C=C3O1
Molecular Formula
C21H20O6
Molecular Weight
368.38
References & Citations
[1]Yuji Sato, et al. Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. J Ethnopharmacol. 2006 May 24;105 (3) :409-14. |[2]Enxiang Zhang, et al. Protective effects of glycycoumarin on liver diseases. Phytother Res. 2020 Jun;34 (6) :1191-1197.|[3]Zhang E, et al. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. Nutrients. 2018 Mar 15;10 (3) :353.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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