Guanosine 5'-diphosphate (sodium), 96% (HPLC)

Guanosine 5'-diphosphate (sodium), 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, Type I, 96% (HPLC) is a potential iron mobilizer, which prevents the hepcidin-ferroportin interaction and modulates the interleukin-6 (IL-6) /stat-3 pathway. Guanosine 5'-diphosphate (sodium), 96% (HPLC) can be used in the research of inflammation, such as anemia of inflammation (AI) [1][2].

Product Specifications

CAS Number

[43139-22-6]

Product Name Alternative

GDP (sodium), Type I, 96% (HPLC)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Hepcidin; Potassium Channel

Type

Biochemical Assay Reagents

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/guanosine-5-diphosphate-sodium.html

Purity

99.88

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=P(OP(O)(O[Na])=O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1

Molecular Formula

C10H14N5NaO11P2

Molecular Weight

465.18

Precautions

H302, H315, H319, H335

References & Citations

[1]S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418. |[2]Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.