15-keto-Prostaglandin E2
Product Specifications
Product Name Alternative
SX 810
UNSPSC Description
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].
Target Antigen
Endogenous Metabolite; PPAR; Prostaglandin Receptor; STAT
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;GPCR/G Protein;JAK/STAT Signaling;Metabolic Enzyme/Protease;Stem Cell/Wnt;Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/15-Keto-prostaglandin_E2.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCCC(/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(O)=O)=O
Molecular Weight
350.45
References & Citations
[1]Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175.|[2]Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022 Dec 1;310:121114.|[3]Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019 Mar 28;15(3):e1007597.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113205/15-keto-Prostaglandin-E2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113205/15-keto-Prostaglandin-E2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
26441-05-4
Available Sizes
Curated Selection
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