SARS-CoV-2 Mpro-IN-2

SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM) . SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies[1].

Product Specifications

CAS Number

[2768834-39-3]

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sars-cov-2-mpro-in-2.html

Purity

98.96

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClC(C=CC(N1CCN(C(C2=CN=CC=C2)=O)C[C@H]1C(NCC3=CC=CS3)=O)=C4)=C4Cl

Molecular Formula

C22H20Cl2N4O2S

Molecular Weight

475.39

References & Citations

[1]Gao S, et al. Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. J Med Chem. 2022 Sep 15:acs.jmedchem.2c01146.