SARS-CoV-2 Mpro-IN-2
SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent Mpro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM) . SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies[1].
Product Specifications
CAS Number
[2768834-39-3]
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-mpro-in-2.html
Purity
98.96
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
ClC(C=CC(N1CCN(C(C2=CN=CC=C2)=O)C[C@H]1C(NCC3=CC=CS3)=O)=C4)=C4Cl
Molecular Formula
C22H20Cl2N4O2S
Molecular Weight
475.39
References & Citations
[1]Gao S, et al. Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity. J Med Chem. 2022 Sep 15:acs.jmedchem.2c01146.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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