Ac-Leu-Val-Lys-Aldehyde

Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807) -induced striatal cell death and causes accumulation of LC3-II[1].

Product Specifications

CAS Number

[147600-40-6]

UNSPSC

12352209

Target

Cathepsin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-leu-val-lys-aldehyde.html

Solubility

10 mM in DMSO

Smiles

CC(C)C[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@H](C=O)CCCCN)=O)=O

Molecular Formula

C19H36N4O4

Molecular Weight

384.51

References & Citations

[1]McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36 (8) :1084-9.|[2]Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8 (9) :e75702.