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ERα degrader 11

ERα degrader 11 (compound B16) is a selective ERα degrader that can be used as an estrogen receptor probe to investigate ER status in ER-positive breast cancer cells[1].

Product Specifications

CAS Number

3052336-87-2

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erα-degrader-11.html

Smiles

CCN(C1=CC(C(F)(F)F)=CC=C1N2CC3=CC=C(O)C=C3CC2)CC4=CC=C(/C=C/C(O)=O)C=C4

Molecular Formula

C28H27F3N2O3

Molecular Weight

496.52

References & Citations

[1]Lu Y, et al. Discovery of non-antiproliferative selective estrogen receptor degraders (SERDs) based on scaffold optimization of elacestrant. Eur J Med Chem. 2024 Sep 21;279:116897.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERα

Frequently Asked Questions

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