PE-Labeled Human TIGIT Protein, His TagStar Staining
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3), which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) . TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level) . TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the C-terminus.
Accession Number
Q495A1-1
Expression Region
Met 22 - Pro 141
Host
HEK293
Target
TIGIT
Conjugation
PE Labeled
Tag
C-10xHis
Source
Human
Stability
Endotoxin
1.0 EU per μg
Format
Powder
Buffer
PBS, 0.2% BSA, pH7.4
Additives
Trehalose
Molecular Weight
41.4 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C, avoid light
Package Size
25tests*1
Host or Source
HEK293
Species
Human
Protein ID
Q495A1-1
Preservative
Trehalose
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