Foscarnet (trisodium hexahydrate)

Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Product Specifications

CAS Number

[34156-56-4]

Product Name Alternative

Trisodium phosphonoformate (hexahydrate) ; Phosphonoformic acid trisodium salt (hexahydrate)

UNSPSC

12352300

Hazard Statement

H341, H373

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/foscarnet-trisodium-hexahydrate.html

Purity

99.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(P(O[Na])(O[Na])=O)O[Na].[6H2O]

Molecular Formula

CH12Na3O11P

Molecular Weight

300.04

Precautions

H341, H373

References & Citations

[1]Zahn KE, Doublié S, et al. Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase. J Biol Chem. 2011 Jul 15;286 (28) :25246-55.|[2]Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium) .Pharmacol Ther. 1982;19 (3) :387-415.|[3]Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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