(R) -Verapamil (hydrochloride)

(R) -Verapamil hydrochloride ((R) - (+) -Verapamil hydrochloride) is an orally active P-Glycoprotein inhibitor. (R) -Verapamil hydrochloride blocks MRP1 mediated transport. (R) -Verapamil hydrochloride induces Apoptosis and inhibits L-type calcium channels BZPcc, DHPcc and PLLcc. (R) -Verapamil hydrochloride has anti-septic shock and anti-diabetic effects[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[38176-02-2]

Product Name Alternative

(R) - (+) -Verapamil (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Apoptosis; Calcium Channel; P-glycoprotein

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-verapamil-hydrochloride.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C=CC(CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C)C)=C1.Cl

Molecular Formula

C27H39ClN2O4

Molecular Weight

491.06

Precautions

H301+H311+H331

References & Citations

[1]Plumb JA, et al. The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific. Biochem Pharmacol. 1990 Feb 15;39 (4) :787-92.|[2]Perrotton T, et al. (R) - and (S) -verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282 (43) :31542-8. Epub 2007 Jul 22.|[3]Faude F, et al. R- (+) -verapamil, S- (-) -verapamil, and racemic verapamil inhibit human retinal pigment epithelial cell contraction. Graefes Arch Clin Exp Ophthalmol. 2000 Jun;238 (6) :537-41.|[4]Karwatsky J, et al. A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity. Biochemistry. 2003 Oct 28;42 (42) :12163-73.|[5]Chen YS, et al. Evaluating the antidiabetic effects of R-verapamil in type 1 and type 2 diabetes mellitus mouse models. PLoS One. 2021 Aug 6;16 (8) :e0255405. |[6]Visani G, et al. Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors. Ann Hematol. 1993 Jun;66 (6) :273-6.|[7]Wyska E. Pretreatment with R (+) -verapamil significantly reduces mortality and cytokine expression in murine model of septic shock. Int Immunopharmacol. 2009 Apr;9 (4) :478-90.