Tramiprosate

Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].

Product Specifications

CAS Number

[3687-18-1]

Product Name Alternative

Homotaurine; 3-Amino-1-propanesulfonic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Tramiprosate.html

Purity

98.0

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

NCCCS(=O)(O)=O

Molecular Formula

C3H9NO3S

Molecular Weight

139.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.|[2]Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28 (4) :537-47.|[3]R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32 (3) :241-5.