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Syk Inhibitor II

Syk Inhibitor II is an ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 41 nM. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk. It prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro and inhibits passive cutaneous anaphylaxis reactions in mice, with an ID₅₀ of 13 mg/kg following subcutaneous administration.

Product Specifications

Shipping Conditions

Gel Pack

Storage Conditions

-20ºC

Shelf Life

36 months

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