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NSC109116

NSC109116 is an inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), an aldo-keto reductase (AKR) enzyme. AKR1C1 metabolizes progesterone to an inactive form, 20α-hydroxy progesterone. NSC109116 is a salicylic compound that selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2. It potently inhibits the metabolism of progesterone in bovine aortic endothelial cells overexpressing AKR1C1 with an IC₅₀ of 460 nM.

Product Specifications

Shipping Conditions

RT

Storage Conditions

-20ºC

Shelf Life

36 months

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