NH125

NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. It inhibits histidine protein kinase YycG with an IC₅₀ of 6.6 µM. It selectively inhibits eEF-2 kinase activity with an IC₅₀ of 60 nM in vitro and weakly inhibits PKC, PKA and CaMK II. It also decreases the viability of several cancer cell lines with IC₅₀ values ranging from 0.7-4.7 µM.