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WHI-P180

WHI-P180 is a multi-kinase inhibitor. It inhibits human proto-oncogene receptor tyrosine kinase RET (Rearranged during Transfection) and kinase insert domain receptor (KDR) with IC₅₀ values of 4.5 nM and 66 nM respectively. It inhibits epidermal growth factor receptor (EGFR) kinase with an IC₅₀ of 4.0 μM and also inhibits Janus kinase 3 (JAK3). It exhibits potent anti-graft-versus-host disease activity and IgE-mediated mast cell responses in vitro and in vivo.

Product Specifications

Shipping Conditions

RT

Storage Conditions

-20ºC

Shelf Life

36 months

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