SAR-131675

SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively. SAR-131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 displays antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.