PD-1/PD-L1-IN-10
Product Specifications
UNSPSC Description
PD-1/PD-L1-IN-10 (compound B2) is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy[1].
Target Antigen
Apoptosis; PD-1/PD-L1
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-10.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C(OCC4=CC(C#N)=CC=C4)=C3)CN[C@H](C(O)=O)C(O)C)[N+]([O-])=O
Molecular Weight
581.62
References & Citations
[1]Yiqiang OuYang, et al. Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo. J Med Chem. 2021 May 26.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132202/PD-1-PD-L1-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132202/PD-1-PD-L1-IN-10-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2487550-41-2
Available Sizes
Curated Selection
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