Chlojaponilactone B
Product Specifications
UNSPSC Description
Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α[1].
Target Antigen
NF-κB; Reactive Oxygen Species; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chlojaponilactone-b.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@](C([C@]3([H])[C@@]2([H])C3)=C)([H])[C@H](C(C(O4)=C1)=C(C)C4=O)OC(C)=O
Molecular Weight
286.32
References & Citations
[1]Shaoxia Ye, et al. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019 Oct 16;24(20):3731.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N8413/Chlojaponilactone-B-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N8413/Chlojaponilactone-B-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1449382-91-5
Available Sizes
Curated Selection
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