Chlojaponilactone B

Chlojaponilactone B is a lindenane-type sesquiterpenoid with anti-inflammatory properties. Chlojaponilactone B suppresses inflammatory responses by inhibiting TLR4 and subsequently decreasing reactive oxygen species (ROS) generation, downregulating the NF-κB, thus reducing the expression of the pro-inflammatory cytokines iNOS, NO, COX-2, IL-6 and TNF-α[1].

Product Specifications

CAS Number

[1449382-91-5]

UNSPSC

12352005

Target

NF-κB; Reactive Oxygen Species (ROS) ; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chlojaponilactone-b.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@](C([C@]3([H])[C@@]2([H])C3)=C)([H])[C@H](C(C(O4)=C1)=C(C)C4=O)OC(C)=O

Molecular Formula

C17H18O4

Molecular Weight

286.32

References & Citations

[1]Shaoxia Ye, et al. Chlojaponilactone B Attenuates Lipopolysaccharide-Induced Inflammatory Responses by Suppressing TLR4-Mediated ROS Generation and NF-κB Signaling Pathway. Molecules. 2019 Oct 16;24 (20) :3731.