Complement C5-IN-1
Product Specifications
UNSPSC Description
Complement C5-IN-1 (Compound 7) is a small-molecule inhibitor of complement component 5 protein (C5). Complement C5-IN-1 interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM[1].
Target Antigen
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/complement-c5-in-1.html
Purity
99.14
Solubility
DMSO : ≥ 100 mg/mL
Smiles
COC1=C(OCCCC(C)C)C=C(NC(N[C@H](C2=C(OC)C=CC=C2)C)=O)C(C(O)=O)=C1
Molecular Weight
444.52
References & Citations
[1]Jendza K, et al. A small-molecule inhibitor of C5 complement protein. Nat Chem Biol. 2019 Jul;15(7):666-668.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128342/Complement-C5-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128342/Complement-C5-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2365402-67-9
Available Sizes
Curated Selection
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