CALP1 (TFA)

CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity[1][2][3][4].

Product Specifications

UNSPSC

12352209

Target

Apoptosis; Calmodulin; mGluR; Phosphodiesterase (PDE)

Type

Peptides

Related Pathways

Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/calp1-tfa.html

Purity

99.86

Solubility

H2O : 16.67 mg/mL (ultrasonic)

Smiles

NCCCC[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C42H76F3N9O12

Molecular Weight

956.10

References & Citations

[1]R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166 (2) :861-7.|[2]R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15 (10) :1831-3.|[3]M K Manion, et al. A new type of Ca (2+) channel blocker that targets Ca (2+) sensors and prevents Ca (2+) -mediated apoptosis. FASEB J. 2000 Jul;14 (10) :1297-306.|[4]M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275 (4) :2676-85.