Episilvestrol

Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia perviridis, and is a specific eIF4A-targeting translation inhibitor, with antitumor activity.

Product Specifications

CAS Number

[697235-39-5]

UNSPSC

12352005

Target

Autophagy; Eukaryotic Initiation Factor (eIF)

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Episilvestrol.html

Purity

99.86

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(O[C@@H]6O[C@@H]([C@@H](O)CO)CO[C@H]6OC)=CC(OC)=C35)OC

Molecular Formula

C34H38O13

Molecular Weight

654.66

References & Citations

[1]Chambers JM, et al. Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II. Org Lett. 2013 Mar 15;15 (6) :1406-9.|[2]Hwang BY, et al. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. J Org Chem. 2004 May 14;69 (10) :3350-8.|[3]Daker M, et al. Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa. Exp Ther Med. 2016 Jun;11 (6) :2117-2126. Epub 2016 Mar 29.