2'-MeCCPA

2'-MeCCPA is a potent and selective A1 adenosine receptors (A1AR) agonist. 2'-MeCCPA efficiently inhibits cAMP modulation in both direct pathway medium spiny neurons (dMSNs) and indirect pathway medium spiny neurons (iMSNs) [1][2].

Product Specifications

CAS Number

[205171-12-6]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-meccpa.html

Purity

99.80

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

ClC1=NC2=C(C(NC3CCCC3)=N1)N=CN2[C@H]4[C@@](O)(C)[C@H](O)[C@@H](CO)O4

Molecular Formula

C16H22ClN5O4

Molecular Weight

383.83

References & Citations

[1]J Bhandal, et al. Adenosine a1 receptor activation can protect the myocardium from ischaemia reperfusion injury post reperfusion. BMJ Journals. Volume 104, Issue Suppl 3.|[2]Muntean BS, et al. Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits. Cell Rep. 2018 Jan 2;22 (1) :255-268.