KY1220

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway, with an IC50 of 2.1 μM in HEK293 reporter cells[1].

Product Specifications

CAS Number

[292168-79-7]

UNSPSC

12352005

Hazard Statement

H302

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/KY1220.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(/C(N1)=C/C2=CC=CN2C3=CC=C([N+]([O-])=O)C=C3)NC1=S

Molecular Formula

C14H10N4O3S

Molecular Weight

314.32

Precautions

H302

References & Citations

[1]Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12 (8) :593-600.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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