Glutaminase-IN-1
Product Specifications
Product Name Alternative
S-18982-d6 (hydrochloride),(±)-4-hydroxy Propranolol (hydrochloride)
UNSPSC Description
Glutaminase-IN-1 (CB839 derivative), a CB839 derivative, is an allosteric inhibitor of 1,3,4-selenadiazole-containing kidney-type glutaminase (KGA), with an IC50 of 1 nM. Glutaminase-IN-1 (CB839 derivative) shows improved cellular uptake and antitumor activity.
Target Antigen
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Glutaminase-IN-1.html
Purity
98.09
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL
Smiles
O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)[Se]1)CC4=NC=CC=C4
Molecular Weight
618.47
References & Citations
[1]Chen Z, et al. Novel 1,3,4-Selenadiazole Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. J Med Chem. 2018 Dec 13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114334/Glutaminase-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114334/Glutaminase-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2247127-79-1
Available Sizes
Curated Selection
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