HS-438
HS-438 is a potent and selective BCR-ABL inhibitor. HS-438 shows antiproliferative activity. HS-438 decreases the expression of phosphorylation of BCR-ABL (Tyr177) . HS-438 induces apoptosis and cell cycle arrest at G0/G1 phase. HS-438 shows antitumor activity. HS-438 has the potential for the research of chronic myeloid leukemia (CML) [1].
Product Specifications
CAS Number
[1430720-10-7]
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hs-438.html
Smiles
O=C(NCCO)NC1=NC2=CC=C(C=C2S1)C3=CC=CC=C3OC
Molecular Formula
C17H17N3O3S
Molecular Weight
343.40
References & Citations
[1]Yun SM, et al. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia. Cancer Lett. 2014 Jun 28;348 (1-2) :50-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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