(Z) -10-Hydroxynortriptyline

(Z) -10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

Product Specifications

CAS Number

[47132-19-4]

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z-10-hydroxy-nortriptyline.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C\CCNC

Molecular Formula

C19H21NO

Molecular Weight

279.38

Precautions

H302

References & Citations

[1]Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22 (4) :371-8.|[2]Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.