Human LGR4 / GPR48 protein, His Tag
The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs) -1–4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.
Product Specifications
Background
The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs) -1–4 and result in Wnt signaling potentiation. In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.8 kDa. The protein migrates as 70-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q9BXB1-1
Expression Region
Ala 25 - Thr 544
Host
HEK293
Target
LGR4
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
85%
Bioactivity
Immobilized Human R‑Spondin 3 at 2 μg/mL (100 μL/well) can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with a linear range of 10-78 ng/mL (QC tested).
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
58.8 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
HEK293
Species
Human
Protein ID
Q9BXB1-1
Preservative
Trehalose
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