Zotepine
Product Specifications
UNSPSC Description
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo[1][2].
Target Antigen
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zotepine.html
Purity
99.85
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(SC2=CC=CC=C2C=C3OCCN(C)C)C3=C1
Molecular Weight
331.86
References & Citations
[1]Richelson E, et, al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39.|[2]Yamamura S, et, al. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex. Br J Pharmacol. 2009 Jun;157(4):656-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103093/Zotepine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103093/Zotepine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
26615-21-4
Available Sizes
Curated Selection
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