CPP-115

CPP-115 is a GABA transaminase inactivator with higher affinity and lower retinal toxicity than Vigabatrin (HY-15399) . CPP-115 increases brain GABA levels by inhibiting GABA transaminase catabolism. CPP-115 can be used in the study of drug addiction and infantile spasms[1].

Product Specifications

CAS Number

[640897-20-7]

UNSPSC

12352211

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cpp-115.html

Smiles

OC([C@H]1C/C([C@H](C1)N)=C(F)\F)=O

Molecular Formula

C7H9F2NO2

Molecular Weight

177.15

References & Citations

[1]Silverman R B, et al. The 2011 EB Hershberg Award for important discoveries in medicinally active substances: (1 S, 3 S) -3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms[J]. Journal of medicinal chemistry, 2012, 55 (2) : 567-575.