IL-17RB, Mouse (HEK293, His)

Product Specifications

UNSPSC Description

IL-17RB (Interleukin 17 receptor B), a protein encoded by the IL17RB gene, is a receptor for the pro-inflammatory cytokines IL17B and IL17E. IL-17RB expression is high in kidney, pancreas, liver, brain, and intestines. IL-17RB may play a role in hematopoietic cell differentiation and growth. IL-17RB is involved in inflammatory diseases and cancers[1][2]. IL-17RB Protein, Mouse (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 269 amino acids (R18-G286).

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-17rb-protein-mouse-269a-a-hek293-his.html

Smiles

REPTIQCGSE TGPSPEWMVQ HTLTPGDLRD LQVELVKTSV AAEEFSILMN ISWILRADAS IRLLKATKIC VSGKNNMNSY SCVRCNYTEA FQSQTRPSGG KWTFSYVGFP VELSTLYLIS AHNIPNANMN EDSPSLSVNF TSPGCLNHVM KYKKQCTEAG SLWDPDITAC KKNEKMVEVN FTTNPLGNRY TILIQRDTTL GFSRVLENKL MRTSVAIPVT EESEGAVVQL TPYLHTCGND CIRREGTVVL CSETSAPIPP DDNRRMLGG

Molecular Weight

38-45 kDa

References & Citations

[1]Lei Ren, et al. IL-17RB enhances thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression. Mol Immunol. 2017 Oct;90:126-135.|[2]Y Shi, et al. A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J Biol Chem. 2000 Jun 23;275(25):19167-76.|[3]Jérémy Bastid, et al. The Emerging Role of the IL-17B/IL-17RB Pathway in Cancer. Front Immunol. 2020 Apr 21;11:718.