Caldaret

Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.

Product Specifications

CAS Number

[133804-44-1]

Product Name Alternative

MCC-135

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Na+/Ca2+ Exchanger

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Caldaret.html

Purity

98.35

Solubility

1 M HCl : 33.33 mg/mL (ultrasonic) |DMSO : 4.81 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)

Smiles

O=S(C1=CC(C)=CC=C1N2CCNCC2)(O)=O

Molecular Formula

C11H16N2O3S

Molecular Weight

256.32

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kawasumi H, et al. Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. J Pharmacol Sci. 2007 Feb;103 (2) :222-33.|[2]Satoh N, et al. Lusitropic effect of MCC-135 is associated with improvement of sarcoplasmic reticulum function in ventricular muscles of rats with diabetic cardiomyopathy. J Pharmacol Exp Ther. 2001 Sep;298 (3) :1161-6.