JP83

JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments[1].

Product Specifications

CAS Number

[887264-44-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

FAAH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jp83.html

Purity

99.0

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=C(NCCCCCCC1=CC=CC=C1)OC2=CC(C3=CC(C(N)=O)=CC=C3)=CC=C2

Molecular Formula

C26H28N2O3

Molecular Weight

416.51

Precautions

H315, H319, H335

References & Citations

[1]Jessica P Alexander, et al. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol. 2005 Nov;12 (11) :1179-87.