PROTAC SMARCA2/4-degrader-27

PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of SMARCA2 and SMARCA4. (Blue: CRL2VHL ligand VH032-cyclopropane-F (HY-125905) ; Black: linker (HY-159678) ; Pink: a SMARCA-BD ligand 1 for PROTAC (HY-44012) ) [1].

Product Specifications

CAS Number

[2375564-54-6]

UNSPSC

12352211

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-4-degrader-27.html

Smiles

O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(C)N=CS4)C=C3)OCCC5=CC=C(C=C5)CN6CCN(C7=C(N)N=NC(C8=C(C=CC=C8)O)=C7)CC6)=O)=O

Molecular Formula

C49H58FN9O6S

Molecular Weight

920.10

References & Citations

[1]Angus D. Cowan, et al. Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. Annu. Rev. Biochem. 2022. 91:295-319.