Glabrone

Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA) . Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3].

Product Specifications

CAS Number

[60008-02-8]

UNSPSC

12352005

Target

Influenza Virus; PPAR

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glabrone.html

Purity

99.08

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2O)=COC4=CC(O)=CC=C14

Molecular Formula

C20H16O5

Molecular Weight

336.34

References & Citations

[1]Grienke U, et al. Computer-guided approach to access the anti-influenza activity of licorice constituents. J Nat Prod. 2014 Mar 28;77 (3) :563-70.|[2]Kuroda M, et al. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010 Jan 15;18 (2) :962-70.|[3]Kuang Y, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. Eur J Pharm Sci. 2021 Jun 1;161:105786.