Argininosuccinate Synthetase (ASS1), E. coli, Recombinant

Argininosuccinate Synthetase is part of the urea cycle. It catalyzes aspartate, citrulline, and ATP to form argininosuccinate. Mutations in the enzyme cause Citrullinemia, preventing the liver from processing nitrogen to urea. Lack of argininosuccinate synthase has also been observed in pancreatic cancer, liver cancer, melanoma