Cis-4-Hydroxy-L-proline (hydrochloride)
Cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product Specifications
CAS Number
441067-49-8
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-4-hydroxy-l-proline-hydrochloride.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
[H]Cl.O=C(O)[C@H]1NC[C@@H](O)C1
Molecular Formula
C5H10ClNO3
Molecular Weight
167.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K3267004 1.0 µg DNA
D1Pas1 sgRNA CRISPR Lentivector (Mouse) (Target 3)
Sign In for Pricing
View Details GTR15362502 1 Vial
Lentiviral human TMEM202 sgRNA gene knockout kit - Lentiviral human TMEM202 sgRNA gene knockout kit (25)
Sign In for Pricing
View Details MBS1425015-01 0.02 mg (E-Coli)
Recombinant Macaca mulatta Inactive serine protease 35 (PRSS35)
Sign In for Pricing
View Details MBS1425015-02 0.02 mg (Yeast)
Recombinant Macaca mulatta Inactive serine protease 35 (PRSS35)
Sign In for Pricing
View Details MBS1425015-03 0.1 mg (E-Coli)
Recombinant Macaca mulatta Inactive serine protease 35 (PRSS35)
Sign In for Pricing
View Details MBS1425015-04 0.1 mg (Yeast)
Recombinant Macaca mulatta Inactive serine protease 35 (PRSS35)
Sign In for Pricing
View Details