4EGI-1

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It reduces the expression of c-Myc, Cyclin D1, Cyclin E, Bcl-2, bFGF and Survivin in human melanoma cells at a concentration of 50 μM. It strongly inhibits tumor growth in xenograft models of human breast and melanoma cancers.