L002

L002 is an inhibitor of p300 histone acetyltransferase (KAT3B). It shows an IC₅₀ of 1.98 μM against p300 in vitro. It inhibits acetylation of histones, p53 and suppresses STAT3 activation. It is cytotoxic to breast cancer cell lines, especially those derived from triple-negative breast cancer cells. It potently suppresses tumor growth and histone acetylation of MDA-MB-468 xenografts.